Use of protamine to augment adenovirus-mediated cancer gene therapy

@article{Lanuti1999UseOP,
  title={Use of protamine to augment adenovirus-mediated cancer gene therapy},
  author={Michael Lanuti and Claude El Kouri and Seth Daniel Force and Mee Young Chang and Kunjlata Manibhai Amin and Kai Xu and Ian A Blair and Larry Robert Kaiser and Steven Mark Albelda},
  journal={Gene Therapy},
  year={1999},
  volume={6},
  pages={1600-1610}
}
Improving the therapeutic potential of adenoviral (Ad) suicide gene therapy has become an area of intense investigation since the inception of gene therapy strategies for cancer treatment. Poor efficiency of gene transfer to target tissues has become one of the most important limitations to Ad-based gene therapy. Since polycations have been shown to enhance adenovirus-mediated gene transfer in epithelial cells both in vitro and in vivo, we hypothesized that polycations could augment treatment… CONTINUE READING
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