Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports.

@article{Evans2001UseOP,
  title={Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports.},
  author={Stephen Jw Evans and Patrick C Waller and Steve Davis},
  journal={Pharmacoepidemiology and drug safety},
  year={2001},
  volume={10 6},
  pages={483-6}
}
BACKGROUND The process of generating 'signals' of possible unrecognized hazards from spontaneous adverse drug reaction reporting data has been likened to looking for a needle in a haystack. However, statistical approaches to the data have been under-utilised. METHODS Using the UK Yellow Card database, we have developed and evaluated a statistical aid to signal generation called a Proportional Reporting Ratio (PRR). The proportion of all reactions to a drug which are for a particular medical… CONTINUE READING
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