Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial.

RATIONALE The duration of antibiotic therapy in critically ill patients with sepsis can result in antibiotic overuse, increasing the risk of developing bacterial resistance. OBJECTIVES To test the hypothesis that an algorithm based on serial measurements of procalcitonin (PCT) allows reduction in the duration of antibiotic therapy compared with empirical… CONTINUE READING