Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial

@article{Bouadma2010UseOP,
  title={Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial},
  author={Lila Bouadma and Charles-Edouard Luyt and Florence Tubach and Christophe Cracco and for the PRORATA trial group},
  journal={The Lancet},
  year={2010},
  volume={375},
  pages={463-474}
}
BACKGROUND Reduced duration of antibiotic treatment might contain the emergence of multidrug-resistant bacteria in intensive care units. We aimed to establish the effectiveness of an algorithm based on the biomarker procalcitonin to reduce antibiotic exposure in this setting. METHODS In this multicentre, prospective, parallel-group, open-label trial, we used an independent, computer-generated randomisation sequence to randomly assign patients in a 1:1 ratio to procalcitonin (n=311 patients… CONTINUE READING
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