Use of prior knowledge for the analysis of high-throughput transcriptomics and metabolomics data

@inproceedings{Reshetova2014UseOP,
  title={Use of prior knowledge for the analysis of high-throughput transcriptomics and metabolomics data},
  author={Polina Reshetova and Age K. Smilde and Antoine H. C. van Kampen and Johan A. Westerhuis},
  booktitle={BMC Systems Biology},
  year={2014}
}
High-throughput omics technologies have enabled the measurement of many genes or metabolites simultaneously. The resulting high dimensional experimental data poses significant challenges to transcriptomics and metabolomics data analysis methods, which may lead to spurious instead of biologically relevant results. One strategy to improve the results is the incorporation of prior biological knowledge in the analysis. This strategy is used to reduce the solution space and/or to focus the analysis… CONTINUE READING

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