Use of phosphonyl carbanions in the synthesis of anti-inflammatory active phosphorus-containing fused heterocycles and relevance phosphonates.

@article{Abdou2010UseOP,
  title={Use of phosphonyl carbanions in the synthesis of anti-inflammatory active phosphorus-containing fused heterocycles and relevance phosphonates.},
  author={W. M. Abdou and A. Kamel and A. Shaddy},
  journal={European journal of medicinal chemistry},
  year={2010},
  volume={45 11},
  pages={
          5217-24
        }
}
The reaction of Horner-Emmons reactant carbanions with 2-acetyl-5-methyl furan 1 and 2-acetyl-5-bromothiophene 9 resulted in phosphorus-containing fused bicyclic 5,5-membered and 5,6-membered systems 5a-c and 12a-c, respectively, as major reaction products along with minor (∼20%) amounts of phosphorylated heterocycles 3a-c and 10a-c. Further treatment of bromo-substituted bicyclic systems 12a-c with the corresponding carbanion proceeded as a substitution of bromine for the residue of the Horner… Expand
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