Use of phosphoimidazolide-activated guanosine to investigate the nucleophilicity of spermine and spermidine.

@article{Kanavarioti1995UseOP,
  title={Use of phosphoimidazolide-activated guanosine to investigate the nucleophilicity of spermine and spermidine.},
  author={A. Kanavarioti and E. Baird and P. Smith},
  journal={The Journal of organic chemistry},
  year={1995},
  volume={60 15},
  pages={
          4873-83
        }
}
Guanosine 5'-phosphate 2-methylimidazolide (2-MeImpG), a labile phosphoimidazolide analog of guanosine triphosphate, was used to test the reactivity of the natural polyamines (PAs), spermine (spm) and spermidine (spd). The products are the guanosine 5'-phosphate-polyamine derivatives (PA-pG: spd-pG and spm-pG) which are quite stable in the range 4 < pH < 11. Our study is the first of which we are aware that reports on the nucleophilicity of these amines. The main findings are as follows. (i… Expand
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