Use of peptide antibodies to probe for the mitoxantrone resistance-associated protein MXR/BCRP/ABCP/ABCG2.

@article{Litman2002UseOP,
  title={Use of peptide antibodies to probe for the mitoxantrone resistance-associated protein MXR/BCRP/ABCP/ABCG2.},
  author={Thomas Litman and Ulla Jensen and Alastair Bierre Hansen and Kuang-Ming Y. Covitz and Zhirong Zhan and Patricia A. Fetsch and Andrea Abati and Paul Robert Hansen and Thomas D. Horn and Torben Skovsgaard and Susan E Bates},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1565 1},
  pages={6-16}
}
Recent studies have characterized the ABC half-transporter associated with mitoxantrone resistance in human cancer cell lines. Encoded by the ABCG2 gene, overexpression confers resistance to camptothecins, as well as to mitoxantrone. We developed four polyclonal antibodies against peptides corresponding to four different epitopes on the mitoxantrone resistance-associated protein, ABCG2. Three epitopes localized on the cytoplasmic region of ABCG2 gave rise to high-affinity antibodies, which were… CONTINUE READING

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