• Biology
  • Published 1986

Use of organ-culture, irradiation and adoptive-transfer to investigate the role of the xenopus thymus in t lymphocyte development

@inproceedings{Russ1986UseOO,
  title={Use of organ-culture, irradiation and adoptive-transfer to investigate the role of the xenopus thymus in t lymphocyte development},
  author={J H Russ},
  year={1986}
}
This Thesis attempts to develop an amphibian model system for exploring the role of the thymus, particularly its stromal cells, in the acquisition of allotolerance. Inbred, clonal and cytogenetically- marked Xenopus are used in this work. The initial experiments (Chapter 2) describe in vitro attempts to deplete the larval and post-metamorphic thymus of its lymphocyte component, while leaving its stromal elements intact. The histologic effects of deoxyguanosine-treatment and 6 -irradiation on… CONTINUE READING

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