Use of oral fluconazole during pregnancy and the risk of birth defects.

  title={Use of oral fluconazole during pregnancy and the risk of birth defects.},
  author={Ditte M\olgaard-Nielsen and Bj{\"o}rn Pasternak and A Hviid},
  journal={The New England journal of medicine},
  volume={369 9},
BACKGROUND Case reports suggest that long-term, high-dose fluconazole treatment for severe fungal infections during pregnancy causes a pattern of birth defects. It is unclear whether commonly used lower doses increase the risk of specific birth defects. METHODS In a registry-based cohort of liveborn infants in Denmark, we evaluated first-trimester oral fluconazole exposure and the risk of birth defects overall and of birth defects previously linked to azole antifungal agents. RESULTS The… CONTINUE READING

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