Use of oligonucleotide aptamer ligands to modulate the function of immune receptors.

@article{Gilboa2013UseOO,
  title={Use of oligonucleotide aptamer ligands to modulate the function of immune receptors.},
  author={Eli Gilboa and James D. Mcnamara and F. Merino Pastor},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 5},
  pages={
          1054-62
        }
}
The paucity of costimulation at the tumor site compromises the ability of tumor-specific T cells to eliminate the tumor. The recent U.S. Food and Drug Administration approval of ipilumimab, an antibody that blocks the inhibitory action of CTLA-4, and clinical trials targeting 4-1BB and PD-1 or PD-L1, have underscored the therapeutic potential of using immunomodulatory antibodies to stimulate protective immunity in human patients. Nonetheless, systemic administration of immunomodulatory… CONTINUE READING

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