Use of normobaric and hyperbaric oxygen in acute focal cerebral ischemia – a preclinical and clinical review

  title={Use of normobaric and hyperbaric oxygen in acute focal cerebral ischemia – a preclinical and clinical review},
  author={Dominik Michalski and Wolfgang H{\"a}rtig and Dietmar Schneider and Carsten Hobohm},
  journal={Acta Neurologica Scandinavica},
Michalski D, Härtig W, Schneider D, Hobohm C. Use of normobaric and hyperbaric oxygen in acute focal cerebral ischemia – a preclinical and clinical review.
Acta Neurol Scand: 2011: 123: 85–97.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard. 
Hyperbaric oxygen therapy and preconditioning for ischemic and hemorrhagic stroke
Hyperbaric oxygen (HBO), an approach through a process in which patients breathe in 100% pure oxygen at over 101 kPa, has been shown to facilitate oxygen delivery and increase oxygen supply, and possesses the potentials to produce beneficial effects on stroke.
Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective
The current literatures on NBO treatment of acute ischemic stroke in preclinical and clinical studies are reviewed and the key gaps or unknowns in the authors' understanding about NBO are identified.
Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N2O for recreational use: a case report
It is hypothesized that the long-term use of N2O may have induced a chronic state of systemic hypoxia that further induced cerebral atrophy with impaired cognitive function and hyperbaric oxygen therapy (HBOT) is reported here for the first time as an important therapeutic element for treating N 2O toxicity due to recreational use.
Hyperbaric oxygen therapy in experimental and clinical stroke
Hyperbaric oxygen therapy in human stroke is still not sufficiently evidence-based, due to the insufficient randomized double-blind controlled clinical studies, and there are no uniform criteria for the dose and session duration of HBOT in different strokes.
Improvement of clinical outcome and cerebral perfusion in a patient of atherosclerotic cerebral infarction after repetitive hyperbaric oxygen treatment--a case report and literature review.
A 56-year-old Chinese man with vascular risk factors has an acute ischemic stroke on the left corona radiata, with right hemiparesis and dysarthria resulting from atherosclerosis, and experiences great improvement after the general course of HBO2T.
Restrictive vs liberal oxygen for trauma patients‐the TRAUMOX1 pilot randomised clinical trial
Whether maintenance of normoxia is feasible using a restrictive oxygen strategy in the initial phase after trauma and the incidence of 30‐day mortality and/or major pulmonary complications is evaluated.
Early outcome and blood-brain barrier integrity after co-administered thrombolysis and hyperbaric oxygenation in experimental stroke
The long-term consequences of simultaneously applied tPA and both NBO and HBO need to be addressed by further studies to identify therapeutic potencies in acute stroke, and to avoid unfavorable courses following combined treatment.
Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke
This article summarizes the current literatures on NBO as a simple, widely accessible, and potentially cost-effective therapeutic strategy for treatment of acute ischemic stroke.
Protection mechanism of early hyperbaric oxygen therapy in rats with permanent cerebral ischemia
It is demonstrated that early hyperbaric oxygen therapy has protective effects on brain tissue after cerebral ischemia, possibly via inhibition of tumor necrosis factor-alpha and phospho-protein kinase C-alpha.


Hyperbaric oxygen in acute ischemic stroke.
  • K. Jain
  • Medicine, Psychology
  • 2003
Previous human studies in stroke patients indicating that 100% oxygen at pressure of 1.5 atm absolute (ATA) is better tolerated than higher pressures by the brain injured by acute ischemia are considered.
Hyperbaric Oxygenation as an Adjunct Therapy in Strokes Due to Thrombosis: A Review of 122 Patients
HBO is used as adjunctive treatment and there appears to be justification for a controlled study to delineate the treatment further, and it is essential to treat patients with stroke at 1.5 to 2 atmospheres absolute (ATA).
Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia
Normobaric hyperoxia may be a clinically feasible adjunct method for significantly increasing the time window for effective thrombolytic therapy in acute ischemic stroke.
Mechanisms of hyperbaric oxygen and neuroprotection in stroke.
Hyperbaric oxygen and cerebral physiology
The literature regarding the effects of HBO on brain oxygenation, cerebral blood flow and intracranial pressure in both the healthy and injured brains are summarized, as well as how changes in these three factors can impart protection.
Therapeutic Window for Use of Hyperbaric Oxygenation in Focal Transient Ischemia in Rats
HBO is highly efficient in reducing infarct volume and improving neurobehavioral outcome in transient MCAO within the first 6 hours, while HBO at later time points (≥12 hours) is harmful by increasing infarCT volume.
A pilot study of hyperbaric oxygen in the treatment of human stroke.
The study was interrupted when it noticed what appeared to be a trend favoring the air-treated patients, whose neurological deficits were less severe and whose infarcts were smaller, and was probably an artifact of the randomization process.
An acute ischemia lesion of the bra in implies a rapid fall to zero of the oxygen tension within central par t s of t h e lesion, and measures which tend to ameliorate circulation anti oxygenation may diminish the final consequences of thc lesion.