Use of nitric oxide-nucleophile adducts as biological sources of nitric oxide: effects on airway smooth muscle.

@article{Hirasaki1996UseON,
  title={Use of nitric oxide-nucleophile adducts as biological sources of nitric oxide: effects on airway smooth muscle.},
  author={G. J. Hirasaki and Keith A. Jones and William A. Perkins and David Oman Warner},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={278 3},
  pages={
          1269-75
        }
}
Nitric oxide (NO)-nucleophile adducts are compounds of the general structure [XN(O)NO]-, where X is a nucleophile residue, and they release NO spontaneously in aqueous solution. This study determined the effects of two NO-nucleophile adducts [diethylaminodiazen-1-ium-1,2-diolate (DEA-NO) and sperminediazen-1-ium-1,2-diolate (DEA-NO) and sperminediazen-1-ium-1,2-diolate (spermine-NO)] on isometric force and the cytosolic concentrations of cyclic GMP ([cGMP]1), cyclic AMP ([cAMP]i) and calcium in… CONTINUE READING

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