Use of neoadjuvant data to design adjuvant endocrine therapy trials for breast cancer

@article{Gonalves2012UseON,
  title={Use of neoadjuvant data to design adjuvant endocrine therapy trials for breast cancer},
  author={Rodrigo Gonçalves and Cynthia Ma and Jingqin Luo and Vera J. Suman and Matthew N Bainbridge},
  journal={Nature Reviews Clinical Oncology},
  year={2012},
  volume={9},
  pages={223-229}
}
Mature outcomes from adjuvant endocrine therapy trials in estrogen receptor-positive breast cancer have enabled comparisons with neoadjuvant clinical trials that have parallel randomizations of treatment in terms of the response of disseminated disease versus the local response within the breast. Imprecise end points, such as 'clinical response', have produced inconsistent results regarding the relationship between neoadjuvant and adjuvant endocrine therapy outcomes. However, the proliferation… CONTINUE READING
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