Use of nanotopography to study mechanotransduction in fibroblasts--methods and perspectives.

@article{Dalby2004UseON,
  title={Use of nanotopography to study mechanotransduction in fibroblasts--methods and perspectives.},
  author={Matthew J. Dalby and Mathis O Riehle and Duncan S Sutherland and Hossein Agheli and Adam S. G. Curtis},
  journal={European journal of cell biology},
  year={2004},
  volume={83 4},
  pages={159-69}
}
The environment around a cell during in vitro culture is unlikely to mimic those in vivo. Preliminary experiments with nanotopography have shown that nanoscale features can strongly influence cell morphology, adhesion, proliferation and gene regulation, but the mechanisms mediating this cell response remain unclear. In this perspective article, we attempt to illustrate that a possible mechanism is direct transmittal of forces encountered by cells during spreading to the nucleus via the… CONTINUE READING