Use of nanoscale delivery systems to maintain synergistic drug ratios in vivo.

@article{Dicko2010UseON,
  title={Use of nanoscale delivery systems to maintain synergistic drug ratios in vivo.},
  author={Awa Dicko and Lawrence D. Mayer and Paul G. Tardi},
  journal={Expert opinion on drug delivery},
  year={2010},
  volume={7 12},
  pages={
          1329-41
        }
}
IMPORTANCE OF THE FIELD Drug combinations have been the standard of care in the treatment of cancer for > 50 years. Typically, combination chemotherapy uses agents with non-overlapping toxicities which are escalated to their maximum tolerated dose. However, emerging evidence indicates that this approach may not be providing optimal efficacy depending on the drug ratios to which the tumor is exposed. Combined drugs can be synergistic whereas other ratios of the same agents may be antagonistic or… CONTINUE READING
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