Use of mutation specific antibodies to detect EGFR status in small biopsy and cytology specimens of lung adenocarcinoma.

@article{Hasanovic2012UseOM,
  title={Use of mutation specific antibodies to detect EGFR status in small biopsy and cytology specimens of lung adenocarcinoma.},
  author={Adnan Hasanovic and Daphne Ang and Andr{\'e} Moreira and Maureen F. Zakowski},
  journal={Lung cancer},
  year={2012},
  volume={77 2},
  pages={
          299-305
        }
}
  • Adnan Hasanovic, Daphne Ang, +1 author Maureen F. Zakowski
  • Published in Lung cancer 2012
  • Medicine
  • BACKGROUND EGFR mutation status is the best predictor of response to tyrosine kinase inhibitors (TKIS) in primary lung adenocarcinoma. Approximately 70% of lung cancers are diagnosed in advanced stages where small biopsies and cytological specimens are the only source of material for both diagnosis and mutation testing. Specific antibodies that can detect mutant EGFR protein were evaluated for the detection of EGFR mutation by immunohistochemistry (IHC) in cytology and small biopsy specimens… CONTINUE READING

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