Use of monoclonal antibodies to identify shared idiotypes on anticardiolipin and anti-DNA antibodies in human sera.

Abstract

Using hybridoma technology we produced monoclonal antibodies (MoAb) to idiotypic determinants on human anti-cardiolipin antibodies purified from a patient with SLE. Hybridomas were screened by inhibition of cardiolipin binding activity of sera from patients with SLE. Seven hybridomas were selected, two of which were studied extensively. Sera from a number… (More)

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@article{Valesini1987UseOM, title={Use of monoclonal antibodies to identify shared idiotypes on anticardiolipin and anti-DNA antibodies in human sera.}, author={Guido Valesini and {\'A}lfio Jos{\'e} Tincani and E. Nathan Harris and Patrizia Mantelli and Fabio Allegri and Gabriella Palmieri and G. R. V. Hughes and Francesco Balsano and Gianpaolo Balestrieri}, journal={Clinical and experimental immunology}, year={1987}, volume={70 1}, pages={18-25} }