Use of monoclonal antibodies in local passive immunization to prevent colonization of human teeth by Streptococcus mutans.

@article{Ma1987UseOM,
  title={Use of monoclonal antibodies in local passive immunization to prevent colonization of human teeth by Streptococcus mutans.},
  author={Julian K.-C. Ma and Roger V. Smith and Thomas Lehner},
  journal={Infection and immunity},
  year={1987},
  volume={55 5},
  pages={
          1274-8
        }
}
Local passive immunization with monoclonal antibodies (MAbs) raised against streptococcal antigen (SA) I/II protects monkeys against colonization of teeth by Streptococcus mutans and the subsequent development of dental caries. In this study we extended the preclinical experiments to human subjects. In the first study of eight healthy subjects, four had anti-SA I/II MAb (immunoglobulin G2a [IgG2a]) and four had saline applied to their teeth on three occasions. A streptomycin-resistant S. mutans… CONTINUE READING

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