Use of monoclonal antibodies in detection of melanoma-associated antigens in intact human tumors.

@article{Thompson1982UseOM,
  title={Use of monoclonal antibodies in detection of melanoma-associated antigens in intact human tumors.},
  author={James J. Thompson and Meenhard Herlyn and David E. Elder and Wallace H. Clark and Zeoon Steplewski and Hilary Koprowski},
  journal={The American journal of pathology},
  year={1982},
  volume={107 3},
  pages={357-61}
}
The use of antimelanoma monoclonal antibodies on tissue sections using a two-step indirect immunoperoxidase technique is reported. Antibodies 691-13-17 and 691-I5-Nu4B reacted with dysplastic nevus cells and all melanomas tested, but not with normal skin melanocytes, intradermal nevi, or lentigines. Antibody 691-13-17, directed against DR antigen, reacted also with Langerhan's cells, macrophages, and a subpopulation of lymphocytes. Antibody 691-I5-Nu4B reacted only with melanomas. The technique… CONTINUE READING

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