Use of monoclonal anti-receptor antibodies to probe the expression of the low density lipoprotein receptor in tissues of normal and Watanabe heritable hyperlipidemic rabbits.

@article{Huettinger1984UseOM,
  title={Use of monoclonal anti-receptor antibodies to probe the expression of the low density lipoprotein receptor in tissues of normal and Watanabe heritable hyperlipidemic rabbits.},
  author={Manfred Huettinger and Wolfgang Johann Schneider and Yiu Kee Ho and Joseph L Goldstein and Michael Scott Brown},
  journal={The Journal of clinical investigation},
  year={1984},
  volume={74 3},
  pages={1017-26}
}
Watanabe Heritable Hyperlipidemic (WHHL) rabbits, like humans with familial hypercholesterolemia, have a genetic defect in the low density lipoprotein (LDL) receptor. WHHL fibroblasts produce a low molecular weight precursor form of the receptor that is not glycosylated normally and is not transported to the cell surface at a normal rate. In the current studies, we have used a monoclonal antibody that reacts with the rabbit LDL receptor to extend these findings to intact rabbits. We have made… CONTINUE READING

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