Use of modified U1 snRNAs to inhibit HIV-1 replication

  title={Use of modified U1 snRNAs to inhibit HIV-1 replication},
  author={Rade Sajic and K. Lee and Kengo Asai and Darinka Sakac and Donald R Branch and Chris Upton and Alan Cochrane},
  booktitle={Nucleic acids research},
Control of RNA processing plays a central role in regulating the replication of HIV-1, in particular the 3' polyadenylation of viral RNA. Based on the demonstration that polyadenylation of mRNAs can be disrupted by the targeted binding of modified U1 snRNA, we examined whether binding of U1 snRNAs to conserved 10 nt regions within the terminal exon of HIV-1 was able to inhibit viral structural protein expression. In this report, we demonstrate that U1 snRNAs complementary to 5 of the 15 regions… CONTINUE READING


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