Use of model cell lines to study the biosynthesis and biological role of cancer-associated sialosyl-Tn antigen.

Abstract

Sialosyl-Tn (STn) is a mucin-associated carbohydrate antigen that is not expressed by most normal epithelial cells but becomes expressed in several types of adenocarcinomas, where it is often associated with a poor prognosis. Little is known about the regulation of the STn phenotype in tumor cells and the immune response to STn antigen. In the present study… (More)

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@article{gata1994UseOM, title={Use of model cell lines to study the biosynthesis and biological role of cancer-associated sialosyl-Tn antigen.}, author={S gata and A. Chen and Steven H. Itzkowitz}, journal={Cancer research}, year={1994}, volume={54 15}, pages={4036-44} }