Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans.

@article{Khetani2013UseOM,
  title={Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans.},
  author={Salman R Khetani and Chitra Kanchagar and Okechukwu Ukairo and Stacy Krzyzewski and Amanda Moore and Julianne Shi and Simon Aoyama and Michael D Aleo and Yvonne Will},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2013},
  volume={132 1},
  pages={107-17}
}
Because drug-induced liver injury (DILI) remains a major reason for late-stage drug attrition, predictive assays are needed that can be deployed throughout the drug discovery process. Clinical DILI can be predicted with a sensitivity of ~50% and a false positive (FP) rate of ~5% using 24-h cultures of sandwich-cultured primary human hepatocytes and imaging of four cell injury endpoints (Xu et al., 2008). We hypothesized that long-term drug dosing in a functionally stable model of primary… CONTINUE READING