Use of methadone in the morphine-tolerant burned paediatric patient.

@article{Williams1998UseOM,
  title={Use of methadone in the morphine-tolerant burned paediatric patient.},
  author={Patrick Williams and Richard E. Sarginson and Jennifer M Ratcliffe},
  journal={British journal of anaesthesia},
  year={1998},
  volume={80 1},
  pages={92-5}
}
We describe the successful use of methadone in the restoration of sedation and provision of analgesia in two morphine-tolerant, paediatric patients who had suffered significant thermal injuries and were undergoing mechanical ventilation. Both patients had exhibited escalating requirements for sedative drugs while undergoing ventilation yet remained inadequately sedated. The introduction of i.v. methadone in place of i.v. morphine in the sedative regimen rapidly and effectively restored a state… CONTINUE READING
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