Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation.

@article{Zhang2012UseOM,
  title={Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation.},
  author={Haiyuan Zhang and Zhaoxia Ji and Tian Xia and Huan Meng and C{\'e}cile Low-Kam and Rong Liu and Suman Pokhrel and Sijie Lin and Xiang Wang and Yu-Pei Liao and Meiying Wang and Linjiang Li and Robert Rallo and Robert Damoiseaux and Donatello Telesca and Lutz M{\"a}dler and Yoram Cohen and Jeffrey I. Zink and Andre E. Nel},
  journal={ACS nano},
  year={2012},
  volume={6 5},
  pages={
          4349-68
        }
}
We demonstrate for 24 metal oxide (MOx) nanoparticles that it is possible to use conduction band energy levels to delineate their toxicological potential at cellular and whole animal levels. Among the materials, the overlap of conduction band energy (E(c)) levels with the cellular redox potential (-4.12 to -4.84 eV) was strongly correlated to the ability of Co(3)O(4), Cr(2)O(3), Ni(2)O(3), Mn(2)O(3), and CoO nanoparticles to induce oxygen radicals, oxidative stress, and inflammation. This… 
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664 Citations

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