Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens.

@article{Knasmller1998UseOM,
  title={Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens.},
  author={Siegfried Knasm{\"u}ller and Wolfram Parzefall and Raman Sanyal and Sonja Ecker and Cornelia M Schwab and Maria Uhl and Volker Mersch-Sundermann and Gary Williamson and G Hietsch and Thomas Langer and Firouz Darroudi and Adayapalam Tyagarajan Natarajan},
  journal={Mutation research},
  year={1998},
  volume={402 1-2},
  pages={185-202}
}
The human hepatoma line (Hep G2) has retained the activities of various phase I and phase II enzymes which play a crucial role in the activation/detoxification of genotoxic procarcinogens and reflect the metabolism of such compounds in vivo better than experimental models with metabolically incompetent cells and exogenous activation mixtures. In the last years, methodologies have been developed which enable the detection of genotoxic effects in Hep G2 cells. Appropriate endpoints are the… CONTINUE READING

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