Use of metabolic pathway flux information in anticancer drug design.

@article{Boros2007UseOM,
  title={Use of metabolic pathway flux information in anticancer drug design.},
  author={L{\'a}szl{\'o} G. Boros and Tiberiu Boros},
  journal={Ernst Schering Foundation symposium proceedings},
  year={2007},
  volume={4},
  pages={189-203}
}
The metabolic phenotype of tumor cells promote the proliferative state, which indicates that (a) cell transformation is associated with the activation of specific metabolic substrate channels toward nucleic acid synthesis and (b) increased expression phosphorylation, allosteric or transcriptional regulation of intermediary metabolic enzymes and their substrate availability together mediate unlimited growth. It is evident that cell transformation due to various K-ras point mutations is… CONTINUE READING