Use of melanotan I and II in the general population

  title={Use of melanotan I and II in the general population},
  author={Michael Evans-Brown and Rob Dawson and M Chandler and Jim McVeigh},
  journal={BMJ : British Medical Journal},
Is unlicensed, unregulated, and potentially harmful 

Gazing into the Scarlet Crystal Ball: Social Work and Hepatitis C

Arguments for recognising and tackling Hepatitis C (HCV) as a major challenge for social work are presented, which will mean a significant expansion of training and awareness-raising among professionals, in addition to strong inter-agency links and a transparent integrated care pathway.

Public health impact and implications of the use of anabolic androgenic steroids (AAS) and associated drugs amongst the male general population

This research has made a significant contribution to the recognition and understanding of the harms associated with the administration of these drugs through injection and the impact of adulterated products as a result of the illicit market.

Melanotan II injection resulting in systemic toxicity and rhabdomyolysis

A 39 year-old Caucasian male injected subcutaneously 6 mg of Melanotan II purchased over the Internet in an attempt to darken his skin during wintertime resulted in systemic toxicity including apparent sympathomimetic symptoms, rhabdomyolysis, and renal dysfunction.

Melanoma Associated with the Use of Melanotan-II

Clinicians are advised to be aware of the problem, and counsel their at-risk patients regarding the potential hazards related to the use of MT-II, as the drug is unlicensed and incompletely tested.

Risks of unregulated use of alpha‐melanocyte‐stimulating hormone analogues: a review

Increasing numbers of case reports indicate that the unregulated use of both melanotan I and II is associated with cutaneous complications, particularly melanocytic changes in existing moles and newly emerging (dysplastic) nevi.

Long‐term observational study of afamelanotide in 115 patients with erythropoietic protoporphyria

Afamelanotide‐induced skin pigmentation has statistically significantly improved light‐tolerance, although the clinical significance of the statistical effect was unknown.

Afamelanotide for prevention of phototoxicity in erythropoietic protoporphyria

In the clinical experience afamelanotide treatment is much more effective in clinical practice than demonstrated in clinical trials and should be made available for all EPP patients meeting inclusion criteria.

Responding to New Psychoactive Substances in the European Union: Early Warning, Risk Assessment, and Control Measures.

The origins of NPS are traced, the work of the EMCDDA is discussed, and a growing number of highly potent substances that can pose a high risk of life-threatening poisoning to users and can cause explosive outbreaks are monitored.

Probiotics for the Prevention of Clostridium difficile–Associated Diarrhea

This review examined the efficacy and safety of probiotics (any strain of bacteria) in patients exposed to broad-spectrum antibiotics.



Melanocortin peptide therapeutics: Historical milestones, clinical studies and commercialization

Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction

The physiological roles of the melanocortin system are outlined, the potential of targeting melanoc Cortin receptors by using MC3 and MC4 agonists for treating weight disorders and sexual dysfunction, andMC4 antagonists to treat anorectic and cachectic conditions are discussed.

New aspects on the melanocortins and their receptors.

A comprehensive review of the pharmacology, physiology and molecular biology of the melanocortins and their receptors is given, and evidence is discussed suggesting that while many of the actions of the pigment are mediated via melanOCortin receptors, some appear to be mediated via mechanisms distinct from melanocorts.

Increased Eumelanin Expression and Tanning is Induced by a Superpotent Melanotropin [Nle4-d-Phe7]-α-MSH in Humans¶

The results show that the tanning induced by MT-I in the face and forearm is associated with a significant increase in the eumelanin content of the human skin.