Use of mechanistic models to estimate low-dose cancer risks.

  • Kenny S. Crump
  • Published 1994 in
    Risk analysis : an official publication of the…
The utility of mechanistic models of cancer for predicting cancer risks at low doses is examined. Based upon a general approximation to the dose-response that is valid at low doses, it is shown that at low doses the dose-response predicted by a mechanistic model is a linear combination of the dose-responses for each of the physiological parameters in the… CONTINUE READING