Use of matrix metalloproteinase (MMP)-9 knockout mice demonstrates that MMP-9 activity is not absolutely required for G-CSF or Flt-3 ligand-induced hematopoietic progenitor cell mobilization or engraftment.

@article{Robinson2003UseOM,
  title={Use of matrix metalloproteinase (MMP)-9 knockout mice demonstrates that MMP-9 activity is not absolutely required for G-CSF or Flt-3 ligand-induced hematopoietic progenitor cell mobilization or engraftment.},
  author={Simon N. Robinson and Vladimir M. Pisarev and Jennifer M Chavez and Rakesh K. Singh and James E Talmadge},
  journal={Stem cells},
  year={2003},
  volume={21 4},
  pages={
          417-27
        }
}
Recombinant growth factors (GFs) are used to mobilize hematopoietic stem cells (HSCs) for autologous and allogeneic transplantation; however, little is known about the mechanism(s) critical to this process. Increased levels of serum matrix metalloproteinase (MMP)-9 are detected during mobilization by G-CSF in humans or interleukin (IL)-8 in primates and mice, suggesting a role for this molecule in mobilization. Further, antibodies to MMP-9 block IL-8-induced mobilization. To investigate the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-6 of 6 extracted citations

Matrix metalloproteinases in stem cell mobilization.

Matrix biology : journal of the International Society for Matrix Biology • 2015
View 1 Excerpt