Use of manometric temperature measurements (MTM) to characterize the freeze-drying behavior of amorphous protein formulations.

@article{Johnson2010UseOM,
  title={Use of manometric temperature measurements (MTM) to characterize the freeze-drying behavior of amorphous protein formulations.},
  author={Robert E. Johnson and Megan E. Oldroyd and Saleem S. Ahmed and Henning Gieseler and Lavinia M. Lewis},
  journal={Journal of pharmaceutical sciences},
  year={2010},
  volume={99 6},
  pages={2863-73}
}
The freeze-drying behavior and cake morphology of a model protein in an amorphous formulation were studied at varying protein concentrations using conservative (-25 degrees C) and aggressive (+25 degrees C) shelf temperatures at constant chamber pressure during primary drying. The two cycles were characterized by manometric temperature measurements (MTM) in a SMART freeze dryer that estimates the sublimation rate (dm/dt), product temperature at the freeze-drying front (T(p-MTM)) and product… CONTINUE READING