Use of mammalian DNA repair-deficient mutants to assess the effects of toxic metal compounds on DNA.

@article{Christie1984UseOM,
  title={Use of mammalian DNA repair-deficient mutants to assess the effects of toxic metal compounds on DNA.},
  author={Nelwyn T. Christie and Orazio Cantoni and Ronald M Evans and Raymond E. Meyn and Max Costa},
  journal={Biochemical pharmacology},
  year={1984},
  volume={33 10},
  pages={1661-70}
}
Wild-type and repair-deficient cell lines ( EM9 ) of Chinese Hamster Ovary cells were utilized to assess cytotoxic responses towards metals that produce lesions in DNA. Alkaline elution studies indicated that both CaCrO4 and HgCl2 induced single-strand breaks in the DNA. CaCrO4 and HgCl2 treatments of intact Chinese hamster ovary cells also caused the induction of DNA cross links. The mutant cells, which are thought to have a defect in the repair polymerase enzyme and therefore exhibit greater… CONTINUE READING

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