Use of magnetic resonance targeting to steer ov-loaded cell-based therapies to tumor sites in vivo

@inproceedings{Muthana2015UseOM,
  title={Use of magnetic resonance targeting to steer ov-loaded cell-based therapies to tumor sites in vivo},
  author={Munitta Muthana and Aneurin J. Kennerley and Emer C. Murphy and Rebekka S. Hughes and J. Conner and Fiona Louise Wright and Mark F. Lythgoe and Jon Dobson and Jim M. Wild and Claire Elizabeth Lewis},
  year={2015}
}
Background Despite considerable progress in the development of cellbased therapies, targeted delivery to specific tissues particularly those deep in the body where direct injection is not possible has been problematic. Here we show that tumour-conditioned macrophages infected with oncolytic HSV Seprehvir display a classic activated (M1) profile characterized by the expression of pro-inflammatory factors such as iNOS, IL-6, IL-8 and tumor necrosis factor-a (TNF-a). Furthermore, the M1… CONTINUE READING
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Use of magnetic resonance targeting to steer ov-loaded cell-based therapies to tumor sites in vivo UK Full list of author information is available at the end of the article

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