Use of low free to total PSA ratio in prostate cancer screening: detection rates, clinical and pathological findings in Brazilian men with serum PSA levels <4.0 ng/mL.

@article{Faria2012UseOL,
  title={Use of low free to total PSA ratio in prostate cancer screening: detection rates, clinical and pathological findings in Brazilian men with serum PSA levels <4.0 ng/mL.},
  author={Eliney Ferreira Faria and Gustavo Franco Carvalhal and Rodolfo Borges dos Reis and M Tobias-machado and Ren{\'e} Aloisio da Costa Vieira and Leonardo Oliveira Reis and Lucas Souza-Carmo Nogueira and Roberto D{\'i}as Machado and Celso Heitor Freitas and Wesley Justino Magnabosco and Edmundo Carvalho Mauad and Andr{\'e} Lopes Carvalho},
  journal={BJU international},
  year={2012},
  volume={110 11 Pt B},
  pages={
          E653-7
        }
}
UNLABELLED What's known on the subject? and What does the study add? In spite of its low specificity, PSA is the most widely used screening test for prostate cancer (PCa), and is considered the main cause of the stage migration recently observed. The ratio of free to total PSA (%fPSA) has been shown to increase PSA accuracy in cancer detection; however, few screening studies have systematically evaluated its role in cancer detection rates in men with PSA levels <4.0 ng/mL and normal DRE. The… CONTINUE READING
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