Use of liposomes as injectable-drug delivery systems.

  title={Use of liposomes as injectable-drug delivery systems.},
  author={Marc J. Ostro and Pieter R. Cullis},
  journal={American journal of hospital pharmacy},
  volume={46 8},
  • M. OstroP. Cullis
  • Published 1 August 1989
  • Biology
  • American journal of hospital pharmacy
The formation of liposomes and their application as delivery systems for injectable drugs are described. Liposomes are microscopic vesicles composed of one or more lipid membranes surrounding discrete aqueous compartments. These vesicles can encapsulate water-soluble drugs in their aqueous spaces and lipid-soluble drugs within the membrane itself. Liposomes release their contents by interacting with cells in one of four ways: adsorption, endocytosis, lipid exchange, or fusion. Liposome… 

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