Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine.

@article{Sirianni2008UseOL,
  title={Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine.},
  author={Archie J Sirianni and Kevin C. Osterhoudt and Diane P. Calello and Allison A Muller and Marie R Waterhouse and Michael B Goodkin and Guy L. Weinberg and Fred M Henretig},
  journal={Annals of emergency medicine},
  year={2008},
  volume={51 4},
  pages={412-5, 415.e1}
}
Animal studies show efficacy of intravenous lipid emulsion in the treatment of severe cardiotoxicity associated with local anesthetics, clomipramine, and verapamil, possibly by trapping such lipophilic drugs in an expanded plasma lipid compartment ("lipid sink"). Recent case reports describe lipid infusion for the successful treatment of refractory cardiac arrest caused by parenteral administration of local anesthetics, but clinical evidence has been lacking for lipid's antidotal efficacy on… CONTINUE READING
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