Use of linkage analysis, genome-wide association studies, and next-generation sequencing in the identification of disease-causing mutations.

@article{Londin2013UseOL,
  title={Use of linkage analysis, genome-wide association studies, and next-generation sequencing in the identification of disease-causing mutations.},
  author={Eric Londin and Priyanka Yadav and Saul Surrey and Larry J. Kricka and Paolo M Fortina},
  journal={Methods in molecular biology},
  year={2013},
  volume={1015},
  pages={127-46}
}
For the past two decades, linkage analysis and genome-wide analysis have greatly advanced our knowledge of the human genome. But despite these successes the genetic architecture of diseases remains unknown. More recently, the availability of next-generation sequencing has dramatically increased our capability for determining DNA sequences that range from large portions of one individual's genome to targeted regions of many genomes in a cohort of interest. In this review, we highlight the… CONTINUE READING

From This Paper

Topics from this paper.
4 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…