Use of lanthanide-grafted inorganic nanoparticles as effective contrast agents for cellular uptake imaging.

@article{Voisin2007UseOL,
  title={Use of lanthanide-grafted inorganic nanoparticles as effective contrast agents for cellular uptake imaging.},
  author={Pierre J Voisin and Emeline J. Ribot and Sylvain Miraux and Anne-Karine Bouzier-Sore and Jean-François Lahitte and V{\'e}ronique Bouchaud and St{\'e}phane Mornet and Eric Thiaudi{\'e}re and Jean-michel Franconi and Lydia Raison and Christine Labrug{\`e}re and Marie-H{\'e}l{\`e}ne Delville},
  journal={Bioconjugate chemistry},
  year={2007},
  volume={18 4},
  pages={1053-63}
}
The improvement of commonly used Gd3+ -based MRI agents requires the design of new systems with optimized in vivo efficacy, pharmacokinetic properties, and specificity. To design these contrast agents, two parameters are usually considered: increasing the number of coordinated water molecules or increasing the rotational correlation time by increasing molecular weight and size. This has been achieved by noncovalent or covalent binding of low-molecular weight Gd3+ chelates to macromolecules or… CONTINUE READING

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