Use of ionic currents to identify and estimate parameters in models of channel blockade.

@article{Starmer1990UseOI,
  title={Use of ionic currents to identify and estimate parameters in models of channel blockade.},
  author={C. Frank Starmer and Vladislav V. Nesterenko and F R Gilliam and Augustus O. Grant},
  journal={The American journal of physiology},
  year={1990},
  volume={259 2 Pt 2},
  pages={H626-34}
}
Models of ion channel blockade are frequently validated with observations of ionic currents resulting from electrical or chemical stimulation. Model parameters for some models (modulated receptor hypothesis) cannot be uniquely determined from ionic currents. The time course of ionic currents reflects the activation (fraction of available channels that… CONTINUE READING