Use of ion channel blockers in the exploration of possible mechanisms involved in the myopathy of diabetic mice


Changes in the muscle contractions of the phrenic nerve-diaphragm preparation from the diabetic mouse were investigated by means of K+- and Cl−-channel blockers and the Ca2+-mobilizing agent, selenite. The K+-channel blockers (UO2 2+ and 4-aminopyridine) cooperated synergistically with the Cl−-channel blockers (Cd2+ and 9-anthracenecarboxylic acid) in… (More)
DOI: 10.1007/BF00169161

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