Use of integrin-linked kinase to extend function of encapsulated pancreatic tissue.

@article{Blanchette2010UseOI,
  title={Use of integrin-linked kinase to extend function of encapsulated pancreatic tissue.},
  author={James O. Blanchette and Steven J Langer and Suchit Sahai and Pritesh S Topiwala and Leslie L Leinwand and Kristi S Anseth},
  journal={Biomedical materials},
  year={2010},
  volume={5 6},
  pages={061001}
}
We have studied the impact of overexpression of an intracellular signaling protein, integrin-linked kinase (ILK), on the survival and function of encapsulated islet tissue used for the treatment of type 1 diabetes. The dimensions of the encapsulated tissue can impact the stresses placed on the tissue and ILK overexpression shows the ability to extend function of dissociated cells as well as intact islets. These results suggest that lost cell-extracellular matrix interactions in cell… CONTINUE READING

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