Use of inhibitors in physiological studies of carbonic anhydrase.

Abstract

The appropriate use of acetazolamide in examining physiological function is based on the following: 1) the dissociation constant of the drug-carbonic anhydrase complex (10(-8) M); 2) the concentration needed to eliminate the catalyzed reaction (10(-4) M can be achieved readily in tissues by giving 20 mg/kg at no toxicity; and 4) the lack of known effects on… (More)

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Cite this paper

@article{Maren1977UseOI, title={Use of inhibitors in physiological studies of carbonic anhydrase.}, author={Thomas H. Maren}, journal={The American journal of physiology}, year={1977}, volume={232 4}, pages={F291-7} }