Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis.

@article{Suzuki2014UseOI,
  title={Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis.},
  author={Takuji Suzuki and Christopher N. Mayhew and Anthony Sallese and Claudia L Chalk and Brenna C. Carey and Punam Malik and Robert W. Wood and Bruce C. Trapnell},
  journal={American journal of respiratory and critical care medicine},
  year={2014},
  volume={189 2},
  pages={
          183-93
        }
}
RATIONALE In patients with pulmonary alveolar proteinosis (PAP) syndrome, disruption of granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling is associated with pathogenic surfactant accumulation from impaired clearance in alveolar macrophages. OBJECTIVES The aim of this study was to overcome these barriers by using monocyte-derived induced pluripotent stem (iPS) cells to recapitulate disease-specific and normal macrophages. METHODS We created iPS cells from two children with… CONTINUE READING
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