Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and non-particulate stimuli.

@article{Singal2005UseOI,
  title={Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and non-particulate stimuli.},
  author={Madhuri Singal and Jacob N. Finkelstein},
  journal={Inhalation toxicology},
  year={2005},
  volume={17 9},
  pages={415-25}
}
Ultrafine particulate matter, from environmental or industrial exposure, can induce the expression of inflammatory mediators and promote the production of reactive oxygen species (ROS), which can damage the alveolar epithelium of the lung. Previous studies have shown that various cellular stresses can activate signaling pathways that operate through the specific transcription factors (TF), AP-1, and nuclear factor (NF)-kappaB that are known to regulate inflammatory gene expression. Persistent… CONTINUE READING