Use of impromidine to define specific histamine H-2 effects on gastric secretion, heart rate and blood pressure in conscious dogs.

E. Molina; J. Rentz; B. Hirschowitz

Corpus ID: 40929767

Use of impromidine to define specific histamine H-2 effects on gastric secretion, heart rate and blood pressure in conscious dogs.

@article{Molina1980UseOI,
  title={Use of impromidine to define specific histamine H-2 effects on gastric secretion, heart rate and blood pressure in conscious dogs.},
  author={E. Molina and J. Rentz and B. Hirschowitz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1980},
  volume={214 3},
  pages={
          483-7
        }
}

E. Molina, J. Rentz, B. Hirschowitz

Published 1980

Chemistry, Medicine

The Journal of pharmacology and experimental therapeutics

Histamine H-2 receptor-mediated effects of the very selective H-2 agonist (H-1:H-2 < 1:1000) impromidine on gastric acid, chloride and pepsin secretion and on heart rate (HR) and systolic blood pressure were compared to those of histamine in five conscious gastric fistula dogs. In each dog, impromidine in a step-dose response (0.46 to 46 nmol/kg.hr) in 45-min steps was given without and with a background infusion of cimetidine (2 mumol/kg.hr). Histamine acid phosphate was given in a seven step… CONTINUE READING

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