Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection.

@article{Pyles2002UseOI,
  title={Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection.},
  author={Richard B Pyles and Debbie Higgins and Claudia L Chalk and Anthony Zalar and Joseph J Eiden and Carrie Brown and Gary Van Nest and Lawrence R Stanberry},
  journal={Journal of virology},
  year={2002},
  volume={76 22},
  pages={11387-96}
}
Synthetic oligonucleotides containing CpG motifs in specific sequence contexts have been shown to induce potent immune responses. We have evaluated mucosal administration of two immunostimulatory sequence (ISS)-containing phosphorothioate-stabilized oligonucleotides for antiherpetic efficacy in animal models. The ISS oligonucleotides, suspended in phosphate-buffered saline, were tested in mouse and guinea pig vaginal models of herpes simplex virus type 2 (HSV-2) infection. For comparison… CONTINUE READING
33 Citations
60 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

Similar Papers

Loading similar papers…