Use of human tissue in ADME and safety profiling of development candidates.

@article{Coleman2001UseOH,
  title={Use of human tissue in ADME and safety profiling of development candidates.},
  author={Robert A. Coleman and Wilbur Pardon Bowen and Ian A. Baines and Amanda J. Woodrooffe and Anthony M. C. Brown},
  journal={Drug discovery today},
  year={2001},
  volume={6 21},
  pages={
          1116-1126
        }
}
The clinical success of a compound is often curtailed because of inadequate safety, pharmacokinetics or efficacy. Human tissue can be used to identify the potential shortcomings of new drugs before they undergo testing in man. This review highlights the consent and ethical approval required for the use of human tissues and discusses their use for predicting human ADME and safety profiles of drugs in preclinical development. The ability to retrieve a wide range of viable tissues from human… CONTINUE READING
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