Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations.

@article{Hewitt2013UseOH,
  title={Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations.},
  author={Nicola J. Hewitt and Robert J. Edwards and Ellen Fritsche and Carsten Goebel and Pierre Aeby and Julia Scheel and Kerstin Reisinger and Gladys Ou{\'e}draogo and Daniel Duch{\'e} and Joan Eilstein and Alain Latil and Julia Kenny and Claire Moore and Jochen Kuehnl and Jo{\~a}o Barroso and Rolf Fautz and Stefan Pfuhler},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2013},
  volume={133 2},
  pages={209-17}
}
Several human skin models employing primary cells and immortalized cell lines used as monocultures or combined to produce reconstituted 3D skin constructs have been developed. Furthermore, these models have been included in European genotoxicity and sensitization/irritation assay validation projects. In order to help interpret data, Cosmetics Europe (formerly COLIPA) facilitated research projects that measured a variety of defined phase I and II enzyme activities and created a complete… CONTINUE READING