Use of human hepatocyte cultures for drug metabolism studies.

@article{Guillouzo1993UseOH,
  title={Use of human hepatocyte cultures for drug metabolism studies.},
  author={Andr{\'e} Guillouzo and Fabrice Morel and Olivier Fardel and Brigitte Meunier},
  journal={Toxicology},
  year={1993},
  volume={82 1-3},
  pages={209-19}
}
Among the in vitro models developed to investigate drug metabolism isolated hepatocytes have become the most powerful model. Human hepatocytes can be prepared from whole livers and surgical wedge biopsies. When placed in culture they retain their specific drug metabolizing activities including inducible cytochrome P450 enzymes for several days. Primary human hepatocyte cultures are now increasingly used for studying drug behavior during preclinical development, e.g. drug interactions… CONTINUE READING

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